Anti-steroidogenic activity of floral extract of Thespesia populnea Corr. in mouse ovary.
نویسندگان
چکیده
Anti-steroidogenic activity of various extracts of T. populnea was screened in female albino mice. The weight of the uterus and ovaries were reduced significantly and the cholesterol and ascorbic acid content in ovaries were significantly elevated due to the treatment with extract of T. populnea. The significant inhibition of delta 5, 3 beta hydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase, the two key enzymes involved in ovarian steroidogenesis were also observed in mouse ovaries after 15 days of treatment.
منابع مشابه
Isolation of an elastase inhibitor, (+)-gossypol from the bark of Thespesia populnea plant
Bioassay guided purification of methanolic extract of the bark of the plant, Thespesia populnea yielded a naphthalene derivative, (+)-gossypol (1). The structure of compound, (+)-gossypol has been established based on its physical and spectral data (UV, IR, H & C NMR and Mass). The compound has been shown moderate elastase inhibition activity when compared with control compound, ursolic acid.
متن کاملEvaluation of antibacterial activity, phenol and flavonoid contents of Thespesia populnea flower extracts.
Flavonoids which were reported as having many pharmacological activities, antimicrobial, antioxidant, cytotoxic, chemoprevention activities and they possess strong antiproliferative effects related to inhibition of cell cycle progression and apoptosis induction. On the basis of this Thespesia populnea (L.) Sol. Ex Correa (Family-Malvaceae) was selected and it is having the major composition of ...
متن کاملSynergistic activity of methanolic extract of Thespesia populnea (Malvaceae) flowers with oxytetracycline
Thespesia populnea (Malvaceae) is a large tree found in tropical regions and coastal forests of India. The bark, leaves, and flowers are useful in cutaneous infections such as scabies, psoriasis, eczema, ringworm, guinea worm and the leaves of this plant used as antiinflammatory for poultice as a folk medicine (Chang et al., 2002). Various parts of T. populnea are found to possess useful medici...
متن کاملEvaluation of anticancer properties of a decoction containing Adenanthera pavonina L. and Thespesia populnea L.
BACKGROUND A decoction composed of Adenanthera pavonina L. and Thespesia populnea L. is currently being used in the treatment of cancer patients. METHODS Lactate Dehydrogenase (LDH) release, (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) MTT, and Sulforhodamine B (SRB) assays were carried out to study cytotoxicity and anti-proliferative activity against the HEp-2 cells, 24 h...
متن کاملAttenuation of expression of cytokines, oxidative stress and inflammation by hepatoprotective phenolic acids from Thespesia populnea Soland ex Correa stem bark
Recently a highly active hepatoprotective phenolic acids fraction (PF) has been isolated from Thespesia populnea stem bark. This fraction showed hepatoprotective action against toxic chemicals such as carbon tetrachloride, acetaminophen and thioacetamide. It also showed in vitro anti-Hepatis B viral activity in cultured cells. In the present study, follow up investigations were carried out to d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Indian journal of experimental biology
دوره 37 12 شماره
صفحات -
تاریخ انتشار 1999